Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest.

@article{Lee2011SerinePI,
  title={Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest.},
  author={Yun-Sang Lee and K Choi and M-H Choi and S-Y Ji and S B Lee and D-M Sin and K-W Oh and Y S Lee and J Hong and Y-P Yun and H-s Yoo},
  journal={Cell proliferation},
  year={2011},
  volume={44 4},
  pages={320-9}
}
OBJECTIVES Melanoma is the most aggressive form of skin cancer, and it resists chemotherapy. Candidate drugs for effective anti-cancer treatment have been sought from natural resources. Here, we have investigated anti-proliferative activity of myriocin, serine palmitoyltransferase inhibitor, in the de novo sphingolipid pathway, and its mechanism in B16F10 melanoma cells. MATERIAL AND METHODS We assessed cell population growth by measuring cell numbers, DNA synthesis, cell cycle progression… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Similar Papers

Loading similar papers…