Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol.

Abstract

Serine palmitoyltransferase (SPT) is the key enzyme for the biosynthesis of sphingolipids. It has been reported that oral administration of myriocin (an SPT inhibitor) decreases plasma sphingomyelin (SM) and cholesterol levels, and reduces atherosclerosis in apoE knockout (KO) mice. We studied cholesterol absorption in myriocin-treated WT or apoE KO animals… (More)
DOI: 10.1016/j.bbalip.2009.01.010

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