Serine hydroxymethyltransferase is maternally essential in Caenorhabditis elegans.

@article{Vatcher1998SerineHI,
  title={Serine hydroxymethyltransferase is maternally essential in Caenorhabditis elegans.},
  author={G P Vatcher and Colin Thacker and Titus Kaletta and Heinke Schnabel and Ralf Schnabel and D. L. Baillie},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 11},
  pages={
          6066-73
        }
}
The mel-32 gene in the free living soil nematode Caenorhabditis elegans encodes a serine hydroxymethyltransferase (SHMT) isoform. Seventeen ethylmethanesulfonate (EMS)-induced mutant alleles of mel-32(SHMT) have been generated, each of which causes a recessive maternal effect lethal phenotype. Animals homozygous for the SHMT mutations have no observable mutant phenotype, but their offspring display an embryonic lethal phenotype. The Mel-32 phenotype has been rescued with a transgenic array… CONTINUE READING

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