• Biology, Medicine
  • Published in
    The Journal of biological…
    1993

Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors.

@article{Moro1993SerineAT,
  title={Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors.},
  author={Osvaldo Moro and Jelveh Lameh and Wolfgang Sadee},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 10},
  pages={
          6862-5
        }
}
Upon agonist exposure, most membrane receptors internalize into the cell as part of an adaptation process. Receptor domains that mediate internalization have been defined for several receptor classes, e.g. growth factor and transport receptors, but not yet for any of the numerous members of the family of G protein-coupled receptors (GPCRs), having seven putative transmembrane helices. With the use of deletion mutations, we previously showed that a small region in the middle of the third… CONTINUE READING

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