Serine Protease Inhibitors Modulate Smoke-Induced Chemokine Release From Human Lung Fibroblasts Running Title: Protease inhibitors and smoke extract

Abstract

Smoking is associated with lung inflammation and a protease-antiprotease imbalance. We previously reported that cigarette smoke extract (CSE) stimulates human lung fibroblasts to release chemotactic cytokines. We hypothesized that serine protease inhibitors might modulate lung fibroblast release of chemotactic cytokines in response to CSE. To test this… (More)

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