Serine Phosphorylation of SR Proteins Is Required for Their Recruitment to Sites of Transcription In Vivo

@article{Misteli1998SerinePO,
  title={Serine Phosphorylation of SR Proteins Is Required for Their Recruitment to Sites of Transcription In Vivo },
  author={Tom Misteli and Javier F C{\'a}ceres and Jade Q. Clement and Adrian R. Krainer and Miles F. Wilkinson and David L. Spector},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={143},
  pages={297 - 307}
}
Expression of most RNA polymerase II transcripts requires the coordinated execution of transcription, splicing, and 3' processing. We have previously shown that upon transcriptional activation of a gene in vivo, pre-mRNA splicing factors are recruited from nuclear speckles, in which they are concentrated, to sites of transcription (Misteli, T., J.F. Cáceres, and D.L. Spector. 1997. Nature. 387:523-527). This recruitment process appears to spatially coordinate transcription and pre-mRNA splicing… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 108 extracted citations

Proteomic and phosphoproteomic analyses reveal extensive phosphorylation of regulatory proteins in developing rice anthers.

The Plant journal : for cell and molecular biology • 2015
View 4 Excerpts
Highly Influenced

Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells.

Investigative ophthalmology & visual science • 2003
View 9 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Cells: A Laboratory Manual

D. L. Spector, R. D. Goldman, L. A. Leinwand.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 105.1– 105.4. • 1998
View 1 Excerpt
Highly Influenced

Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles.

Biochemical and biophysical research communications • 1998
View 4 Excerpts
Highly Influenced

A CTD function linking transcription to splicing.

Trends in biochemical sciences • 1997
View 4 Excerpts
Highly Influenced

Targeting of U2AF65 to Sites of Active Splicing in the Nucleus

The Journal of cell biology • 1997
View 5 Excerpts
Highly Influenced

A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…