Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

@article{Matsumoto2011Serine4P,
  title={Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.},
  author={Gen Matsumoto and Koji Wada and Misako Okuno and Masaru Kurosawa and Nobuyuki Nukina},
  journal={Molecular cell},
  year={2011},
  volume={44 2},
  pages={279-89}
}
Selective macroautophagy (autophagy) of ubiquitinated protein is implicated as a compensatory mechanism of the ubiquitin-proteasome system. p62/SQSTM1 is a key molecule managing autophagic clearance of polyubiquitinated proteins. However, little is known about mechanisms controlling autophagic degradation of polyubiquitinated proteins. Here, we show that… CONTINUE READING