Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.

Abstract

alpha(2)-adrenergic receptors (alpha(2)AR) couple to multiple effectors including adenylyl cyclase and phospholipase C. We hypothesized that signaling selectivity to these effectors is dynamically directed by kinase-sensitive domains within the third intracellular loop of the receptor. Substitution of Ala for Ser232, which is in the N-terminal region of… (More)

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Cite this paper

@article{Liang2001Serine2O, title={Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.}, author={M Liang and Neil J. Freedman and Cheryl T Theiss and Stephen B. Liggett}, journal={Biochemistry}, year={2001}, volume={40 49}, pages={15031-7} }