Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.

@article{Bonni1995Serine1C,
  title={Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.},
  author={Azad Bonni and David D Ginty and Henryk Dudek and Michael E. Greenberg},
  journal={Molecular and cellular neurosciences},
  year={1995},
  volume={6 2},
  pages={168-83}
}
A mechanism has been characterized by which the transcription factor CREB regulates neurotrophin-induced gene expression. Whereas CREB can mediate calcium- or cyclic AMP-induced c-fos transcription independently of other promoter-bound transcription factors, CREB mediates NGF induction of c-fos transcription via a novel mechanism that appears to require a cooperative interaction with another transcription factor, the serum response factor. A similar transcriptional mechanism may explain how… CONTINUE READING
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