Serine/threonine protein kinases synergistically regulate phospholipase D1 and 2 and secretion in RBL-2H3 mast cells.

@article{Chahdi2002SerinethreoninePK,
  title={Serine/threonine protein kinases synergistically regulate phospholipase D1 and 2 and secretion in RBL-2H3 mast cells.},
  author={A. Ouazzani Chahdi and Wahn Soo Choi and Young Mi Kim and Paul F Fraundorfer and Michael A. Beaven},
  journal={Molecular immunology},
  year={2002},
  volume={38 16-18},
  pages={1269-76}
}
The role of phospholipase (PL) D in secretion was examined in RBL-2H3 mast cells which contain both PLD1 and 2. The effects of pharmacologic stimulants and inhibitors of Ca(2+)/calmodulin-dependent kinase II, protein kinase C, and protein kinase A suggested that all three kinases synergistically stimulate PLD and, when associated with a calcium signal, secretion as well to indicate a possible linkage between these two events. Overexpression of either PLD1 or 2 markedly enhanced the activation… CONTINUE READING

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