Series resistance compensation for whole-cell patch-clamp studies using a membrane state estimator.

@article{Sherman1999SeriesRC,
  title={Series resistance compensation for whole-cell patch-clamp studies using a membrane state estimator.},
  author={Arthur Sherman and Alvin Shrier and Emily Cooper},
  journal={Biophysical journal},
  year={1999},
  volume={77 5},
  pages={2590-601}
}
Whole-cell patch-clamp techniques are widely used to measure membrane currents from isolated cells. While suitable for a broad range of ionic currents, the series resistance (R(s)) of the recording pipette limits the bandwidth of the whole-cell configuration, making it difficult to measure rapid ionic currents. To increase bandwidth, it is necessary to compensate for R(s). Most methods of R(s) compensation become unstable at high bandwidth, making them hard to use. We describe a novel method of… CONTINUE READING
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