Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.

@article{Watts2014SerialPO,
  title={Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.},
  author={Joel C. Watts and Carlo Condello and Jan St{\"o}hr and Abby Oehler and Joanne Lee and Stephen J. DeArmond and Lars Lannfelt and Martin Ingelsson and Kurt Giles and Stanley B Prusiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 28},
  pages={10323-8}
}
An increasing number of studies argues that self-propagating protein conformations (i.e., prions) feature in the pathogenesis of several common neurodegenerative diseases. Mounting evidence contends that aggregates of the amyloid-β (Aβ) peptide become self-propagating in Alzheimer's disease (AD) patients. An important characteristic of prions is their ability to replicate distinct strains, the biological information for which is enciphered within different conformations of protein aggregates… CONTINUE READING
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