Serial plasma lactate measurements in haematological patients with neutropenic fever.

Abstract

Elevated plasma lactate and impaired lactate clearance have been associated with poor outcome in patients with severe sepsis. No data are available on the kinetics or prognostic value of plasma lactate in haematological patients with neutropenic fever. A total of 70 haematological patients with 94 episodes of neutropenic fever were included into this prospective study during the period 2006-2008. The median age of the patients was 56 (range 18-70) y. Nineteen patients received therapy for acute myeloid leukaemia and 51 patients received autologous stem cell transplantation. At the onset and on days 1, 2, and 3 of each neutropenic fever episode, plasma lactate and serum C-reactive protein were determined. Criteria for severe sepsis were fulfilled in 13 neutropenic episodes. An elevated plasma lactate level was infrequent at the start of neutropenic fever (5%). There was no association of lactate level with the development of severe sepsis. Two patients died of septic shock, 1 patient with an exceptionally high and increasing level of lactate and the other patient with a normal lactate level. An elevated plasma lactate level at the start of neutropenic fever is not common and does not indicate severe sepsis, but high lactate and an impaired lactate decrease may signify a fatal course in neutropenic fever.

DOI: 10.3109/00365540903338113

Statistics

0100020002011201220132014201520162017
Citations per Year

245 Citations

Semantic Scholar estimates that this publication has 245 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Juutilainen2010SerialPL, title={Serial plasma lactate measurements in haematological patients with neutropenic fever.}, author={Auni M Juutilainen and Sari H{\"a}m{\"a}l{\"a}inen and Irma H Matinlauri and Taru Kuittinen and Tapio Nousiainen and Kari Pulkki and I. H. Koivula and Esa Jantunen}, journal={Scandinavian journal of infectious diseases}, year={2010}, volume={42 2}, pages={102-8} }