Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

@article{Yaffe1977SerialPA,
  title={Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle},
  author={David Yaffe and O Saxel},
  journal={Nature},
  year={1977},
  volume={270},
  pages={725-727}
}
THE muscular dystrophies are a group of hereditary disorders manifested by a progressive wasting of the skeletal muscles. In spite of extensive studies, the nature of the primary lesion is unknown (for review see ref. 1). Because of the complex interaction between tissues, it is difficult to study this question in vivo. Therefore attempts have been made to investigate this question in cultures of dystrophic muscles of human or animal origin. Tissue explants as well as monolayer primary cell… Expand
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Dfferentiation properties of a cell line, L84, which originated from a non-fusing clone isolated from the myogenic line L8, are described and show that L84 cells retain the programme for their differentiation into muscle fibres. Expand
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