Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography.

@article{Hariri2007SerialEI,
  title={Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography.},
  author={Lida P. Hariri and Ziping Qiu and Alexandre R. Tumlinson and David G. Besselsen and Eugene W. Gerner and Natalia A. Ignatenko and Boris Povazay and Boris Hermann and Harald Sattmann and James M. McNally and Angelika Unterhuber and Wolfgang Drexler and Jennifer K. Barton},
  journal={Cancer biology & therapy},
  year={2007},
  volume={6 11},
  pages={1753-62}
}
PURPOSE Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) treated A/J mouse models of CRC in order to monitor the progression of neoplastic transformations and determine if OCT is capable of identifying early disease. EXPERIMENTAL DESIGN… CONTINUE READING