Serial creatinine kinase (CK) MB testing during the emergency department evaluation of chest pain: utility of a 2-hour deltaCK-MB of +1.6ng/ml.

@article{Fesmire1998SerialCK,
  title={Serial creatinine kinase (CK) MB testing during the emergency department evaluation of chest pain: utility of a 2-hour deltaCK-MB of +1.6ng/ml.},
  author={Francis M. Fesmire and Robert F Percy and J B Bardoner and David R Wharton and F B Calhoun},
  journal={American heart journal},
  year={1998},
  volume={136 2},
  pages={237-44}
}
BACKGROUND Traditional methods of using creatinine kinase (CK)-MB to diagnose acute myocardial necrosis rely on the total CK-MB exceeding a threshold of normalcy before being considered diagnostic. Because the CK-MB rapid immunoassay is both sensitive and precise, a small difference between two serial samples over an appropriate time interval may result in an increased sensitivity for acute myocardial infarction (AMI) compared with traditional methods if an appropriate cutoff value is chosen… CONTINUE READING

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