Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.

@article{Li2011SerglycinIA,
  title={Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.},
  author={Xin-jian Li and Choon Kiat Ong and Yun Cao and Yan-qun Xiang and J Shao and Aikseng Ooi and Li-Xia Peng and Wen-hua Lu and Zhongfa Zhang and David Petillo and Li Qin and Ying-Na Bao and Fang-Jing Zheng and Claramae Shulyn Chia and N Gopalakrishna Iyer and Tiebang Kang and Yi-xin Zeng and Khee Chee Soo and Jeffrey M. Trent and Bin Tean Teh and Chao-nan Qian},
  journal={Cancer research},
  year={2011},
  volume={71 8},
  pages={3162-72}
}
Nasopharyngeal carcinoma (NPC) is known for its high-metastatic potential. Here we report the identification of the proteoglycan serglycin as a functionally significant regulator of metastasis in this setting. Comparative genomic expression profiling of NPC cell line clones with high- and low-metastatic potential revealed the serglycin gene (SRGN) as one of the most upregulated genes in highly metastatic cells. RNAi-mediated inhibition of serglycin expression blocked serglycin secretion and the… CONTINUE READING