Serglycin-binding proteins in activated macrophages and platelets.

  title={Serglycin-binding proteins in activated macrophages and platelets.},
  author={Svein Olav Kolset and David M. Mann and Lars Uhlin-Hansen and Jan-Olof Winberg and Erkki Ruoslahti},
  journal={Journal of leukocyte biology},
  volume={59 4},
The major proteoglycan in macrophages and platelets is the chondroitin sulphate proteoglycan serglycin. To study the biological role of serglycin, its binding to secreted and cell-associated proteins from macrophages and blood platelets was examined. Affinity chromatography with serglycin-Sepharose and chondroitin sulphate-Sepharose was used to isolate proteoglycin-binding proteins from macrophages and platelets. Antibodies against human macrophage inflammatory protein-1 alpha (MIP-1 alpha… CONTINUE READING


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