Serenoa Repens Induces Growth Arrest, Apoptosis and Inactivation of STAT3 Signaling in Human Glioma Cells.

@article{Zhou2015SerenoaRI,
  title={Serenoa Repens Induces Growth Arrest, Apoptosis and Inactivation of STAT3 Signaling in Human Glioma Cells.},
  author={Tiezhu Zhou and Yang Yang and Hongyan Zhang and Yuqin Che and Wei Wang and Hui Lv and Jie Li and Yuanyuan Wang and Shuai Hou},
  journal={Technology in cancer research & treatment},
  year={2015},
  volume={14 6},
  pages={
          729-36
        }
}
Serenoa repens, the extract of berry in Southeastern United States, is one of several phytotherapeutic agents available for the treatment of Benign prostatic hyperplasia (BPH). In this study, we found for the first time that Serenoa repens effectively inhibited the growth of human U87 and U251 glioma cells. Flow cytometry assay showed that Serenoa repens induced apoptosis of U87 and U251 glioma cells in a dose-dependent manner. Also, Serenoa repens increased the expression of cleaved-PARP… CONTINUE READING
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