Sera from patients with falciparum malaria induce substance P gene expression in cultured human brain microvascular endothelial cells.

@article{Chiwakata1996SeraFP,
  title={Sera from patients with falciparum malaria induce substance P gene expression in cultured human brain microvascular endothelial cells.},
  author={Collins Batsirai Chiwakata and G M Hort and Ch. J. Hemmer and Manfred Dietrich},
  journal={Infection and immunity},
  year={1996},
  volume={64 12},
  pages={5106-10}
}
Substance P is a pluripotent neuropeptide capable of inducing neurogenic inflammation, immunoregulation, and vasodilatation. In an effort to contribute to the understanding of the pathophysiology of cerebral malaria, we have evaluated the effects of sera obtained from patients suffering from severe or mild malaria and from a healthy donor with no previous… CONTINUE READING