Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cells.

@article{Yamazaki2003SeraFL,
  title={Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cells.},
  author={Shintaro Yamazaki and Kenji Miki and Kiyoshi Hasegawa and Masataka Sata and Tadatoshi Takayama and Masatoshi Makuuchi},
  journal={Journal of hepatology},
  year={2003},
  volume={39 1},
  pages={17-23}
}
BACKGROUND/AIMS The plasticity of bone marrow cells (BMCs) is shown by their ability to differentiate into mesenchymal as well as endodermal and ectodermal lineages. Transdifferentiation of BMCs into hepatocytes has also been demonstrated, both in vitro and in vivo. In the present study we investigated the effects of liver nonparenchymal cells (NPCs) and sera from liver failure patients (HSLF) on the in vitro transdifferentiation of murine BMCs into hepatocytes. METHODS Liver NPCs from wild… CONTINUE READING

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