Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide.

  title={Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide.},
  author={Doron Schwartz and David M Geller and Pamela T. Manning and Norbert Siegel and Kam F Fok and C. I. Edvard Smith and Philip Needleman},
  volume={229 4711},
Vasopressin induces a concentration-dependent increase in atriopeptin immunoreactivity in plasma. Rat plasma, rat atrial extract, and synthetic atriopeptin III (APIII) produced parallel displacement curves of iodine-125-labeled APIII binding to specific antiserum. Fractionation of plasma atriopeptin immunoreactivity by reverse-phase high-performance liquid chromatography showed that the major portion consists of two species of low molecular weight peptides in a ratio of 10 to 1. Both peaks… CONTINUE READING


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