Sequestrin, a CD36 recognition protein on Plasmodium falciparum malaria-infected erythrocytes identified by anti-idiotype antibodies.

@article{Ockenhouse1991SequestrinAC,
  title={Sequestrin, a CD36 recognition protein on Plasmodium falciparum malaria-infected erythrocytes identified by anti-idiotype antibodies.},
  author={Christopher Ockenhouse and F W Klotz and Narendra N. Tandon and Gordon A. Jamieson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 8},
  pages={3175-9}
}
The CD36 molecule expressed by human endothelial cells is a receptor for the adhesion of erythrocytes infected with the human malaria parasite Plasmodium falciparum. A CD36-specific monoclonal antibody, OKM8, inhibits the adhesion of malaria-infected erythrocytes (IRBC) to purified CD36 and cells expressing CD36. Monospecific polyclonal anti-idiotype (anti-Id) antibodies, raised against monoclonal antibody OKM8, expressed determinants molecularly mimicking the CD36 binding domain for the… CONTINUE READING

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