Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

  title={Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo},
  author={Leila M. Luheshi and Wolfgang Hoyer and Teresa Pereira de Barros and Iris van Dijk H{\"a}rd and Ann-Christin Brorsson and Bertil Macao and Cecilia Persson and Damian C Crowther and David A. Lomas and Stefan St{\aa}hl and Christopher M. Dobson and Torleif H{\"a}rd},
  booktitle={PLoS biology},
Protein aggregation, arising from the failure of the cell to regulate the synthesis or degradation of aggregation-prone proteins, underlies many neurodegenerative disorders. However, the balance between the synthesis, clearance, and assembly of misfolded proteins into neurotoxic aggregates remains poorly understood. Here we study the effects of modulating this balance for the amyloid-beta (Abeta) peptide by using a small engineered binding protein (Z(Abeta3)) that binds with nanomolar affinity… CONTINUE READING

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