Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.

@article{Boretti2009SequestrationOE,
  title={Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.},
  author={F S Boretti and Paul B{\"u}hler and Felice D'Agnillo and Katharina Kluge and Tony M. Glaus and Omer I. Butt and Yiping Jia and Jeroen Simon Goede and Claudia Pinto Pereira and Marco Maggiorini and Gabriele Schoedon and Abdu I Alayash and Dominik J Schaer},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 8},
  pages={2271-80}
}
Release of hemoglobin (Hb) into the circulation is a central pathophysiologic event that contributes to morbidity and mortality in chronic hemolytic anemias and severe malaria. These toxicities arise from Hb-mediated vasoactivity, possibly due to NO scavenging and localized tissue oxidative processes. Currently, there is no established treatment that targets circulating extracellular Hb. Here, we assessed the role of haptoglobin (Hp), the primary scavenger of Hb in the circulation, in limiting… CONTINUE READING