Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques.

@article{Ginsberg1997SequestrationOR,
  title={Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques.},
  author={Stephen D Ginsberg and Peter B. Crino and Virginia M-Y Lee and James H. Eberwine and John Q. Trojanowski},
  journal={Annals of neurology},
  year={1997},
  volume={41 2},
  pages={200-9}
}
The polypeptide composition of neurofibrillary tangles (NFTs) and senile plaques (SPs) has been characterized extensively within the Alzheimer's disease (AD) brain. Because few data exist on the nonproteinaceous components of these lesions, we sought to determine if NFTs, neuropil threads (NTs), and SPs contain RNA species. To accomplish this, acridine orange (AO) histofluorescence was employed, alone or in combination with thioflavine S (TS) staining and immunohistochemistry to identify RNAs… CONTINUE READING
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