Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis.

@article{Groves2010SequesteringOR,
  title={Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis.},
  author={Eleanor Groves and Katrin Rittinger and Marlise Amstutz and Sara Berry and David W. Holden and Guy Richard Cornelis and Emmanuelle Caron},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 6},
  pages={4087-98}
}
Pathogenic Yersinia species neutralize innate immune mechanisms by injecting type three secretion effectors into immune cells, altering cell signaling. Our study elucidates how one of these effectors, YopO, blocks phagocytosis. We demonstrate using different phagocytic models that YopO specifically blocks Rac-dependent Fcgamma receptor internalization pathway but not complement receptor 3-dependent uptake, which is controlled by Rho activity. We show that YopO prevents Rac activation but does… CONTINUE READING
18 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.

YopO, a Rac-targeting Membrane-bound GDI 4098 JOURNAL OF BIOLOGICAL CHEMISTRY

  • P. Adamson, H. F. Paterson, A. andHall
  • J. Cell Biol
  • 1992

Similar Papers

Loading similar papers…