Sequential versus simultaneous use of vinorelbine and capecitabine at the same dosage as first-line chemotherapy for patients with metastatic breast cancer

@article{Gu2010SequentialVS,
  title={Sequential versus simultaneous use of vinorelbine and capecitabine at the same dosage as first-line chemotherapy for patients with metastatic breast cancer},
  author={Shi-yang Gu and Ping Zhang and Zhen Jia and Biyun Wang and Jian Zhang and Zhonghua Wang and Haiyi Guo and Jialei Wang and Xinmin Zhao and Xichun Hu},
  journal={The Chinese-German Journal of Clinical Oncology},
  year={2010},
  volume={9},
  pages={528-535}
}
ObjectiveIt remains unclear whether simultaneous use of two chemotherapeutic drugs is better than sequential use. This trial was designed to explore efficacy and safety of sequential vs simultaneous use of vinorelbine and capecitabine at the same dosage as first-line therapy in metastatic breast cancer (MBC).MethodsThis was a un-icenter, randomized phase II trial. Patients randomized into the simultaneous group (group A) were simultaneously administered with vinorelbine and capecitabine while… CONTINUE READING