Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial.

@article{Koopman2007SequentialVC,
  title={Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial.},
  author={Miriam Koopman and Ninja F Antonini and Joep Douma and Jaap Wals and Aafke H. Honkoop and Frans Lg Erdkamp and Robert S de Jong and Cees J Rodenburg and Gerard Vreugdenhil and Olaf J L Loosveld and Aart van Bochove and Harm A. M. Sinnige and G. J. M. Creemers and Margot Et Tesselaar and Peter H Th J Slee and Marjon Jbp Werter and Linda Mol and Otilia B Dalesio and Cornelis J. A. Punt},
  journal={Lancet},
  year={2007},
  volume={370 9582},
  pages={
          135-142
        }
}
BACKGROUND The optimum use of cytotoxic drugs for advanced colorectal cancer has not been defined. Our aim was to investigate whether combination treatment is better than sequential administration of the same drugs in patients with advanced colorectal cancer. METHODS We randomly assigned 820 patients with advanced colorectal cancer to receive either first-line treatment with capecitabine, second-line irinotecan, and third-line capecitabine plus oxaliplatin (sequential treatment; n=410) or… CONTINUE READING
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