Sequential use of novel therapeutics in advanced prostate cancer following docetaxel chemotherapy.

@article{Omlin2014SequentialUO,
  title={Sequential use of novel therapeutics in advanced prostate cancer following docetaxel chemotherapy.},
  author={Aurelius Gabriel Omlin and Carmel Jo Pezaro and Silke Gillessen Sommer},
  journal={Therapeutic advances in urology},
  year={2014},
  volume={6 1},
  pages={3-14}
}
In the last three years, five novel treatments have been shown to improve survival in metastatic castration-resistant prostate cancer (CRPC). These novel treatments have distinct mechanisms of action: tubulin-binding chemotherapy (cabazitaxel); immunotherapy (sipuleucel-T); CYP-17 inhibition (abiraterone); androgen receptor (AR) blockade (enzalutamide); and radioisotope therapy (radium-223). For a number of years, docetaxel was the only treatment with a proven survival benefit for patients with… CONTINUE READING
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