Sequential ultrastructural and biochemical changes induced by microcystin-LR in isolated perfused rat livers.

@article{Wickstrom1996SequentialUA,
  title={Sequential ultrastructural and biochemical changes induced by microcystin-LR in isolated perfused rat livers.},
  author={Mark L. Wickstrom and Wanda M. Haschek and Gerry Henningsen and Leslie A. Miller and John F Wyman and Val Richard Beasley},
  journal={Natural toxins},
  year={1996},
  volume={4 5},
  pages={195-205}
}
The cyanobacterial hepatotoxin, microcystin-LR (MCLR), is a potent protein phosphatase inhibitor that disrupts actin microfilament, cytokeratin intermediate filament, and microtubule networks in hepatocytes. To determine ultrastructural and biochemical changes that develop concurrently with microcystin-induced cytoskeletal disorganization, isolated rat livers were perfused with MCLR at 0.1 to 5.0 micrograms/ml for 5 to 40 min. Lactate dehydrogenase, alanine aminotransferase, and aspartate… CONTINUE READING
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