Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial.

@article{George2003SequentialTO,
  title={Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial.},
  author={Susan Shanti George and Korula George and Christina Irwin and Victoria Job and R. Selvakumar and Visalakshi Jeyaseelan and Mandalam Subramanian Seshadri},
  journal={Human reproduction},
  year={2003},
  volume={18 2},
  pages={299-304}
}
BACKGROUND Recognition of the importance of insulin resistance in clomiphene-resistant women with polycystic ovary syndrome (PCOS) has led to the use of insulin sensitizers. METHODS A randomized, controlled trial was conducted to compare efficacy of sequential treatment with metformin and clomiphene citrate with conventional gonadotrophins. Sixty clomiphene-resistant women with PCOS were randomized to two groups (n = 30 each), using computer-generated tables. Group I received metformin for 6… CONTINUE READING