Corpus ID: 1849114

Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine: preclinical studies.

@article{Mohammad1998SequentialTO,
  title={Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine: preclinical studies.},
  author={R. Mohammad and K. Katato and V. P. Almatchy and N. Wall and K. Liu and C. P. Schultz and H. Mantsch and M. Varterasian and A. Al-Katib},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1998},
  volume={4 2},
  pages={
          445-53
        }
}
  • R. Mohammad, K. Katato, +6 authors A. Al-Katib
  • Published 1998
  • Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • We have previously reported that bryostation 1 (Bryo 1) induces differentiation of chronic lymphocytic leukemia (CLL) in vitro to a hairy cell (HC) stage. This study tests the hypothesis that Bryo 1-differentiated CLL cells are more susceptible to 2-chlorodeoxyadenosine (2-CdA) than parent CLL cells. A recently established EBV-negative CLL line (WSU-CLL) from a patient resistant to chemotherapy including fludarabine was used to test this hypothesis. Both Bryo 1 (10-1000 nM) and 2-CdA (5.6-22.4… CONTINUE READING
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