Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.

@article{Wiegers1998SequentialSI,
  title={Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.},
  author={Klaus Wiegers and Gabriel Rutter and H Kottler and Uwe Tessmer and Heinz Hohenberg and Hans Georg Kraeusslich},
  journal={Journal of virology},
  year={1998},
  volume={72 4},
  pages={2846-54}
}
Retroviruses are produced as immature particles containing structural polyproteins, which are subsequently cleaved by the viral proteinase (PR). Extracellular maturation leads to condensation of the spherical core to a capsid shell formed by the capsid (CA) protein, which encases the genomic RNA complexed with nucleocapsid (NC) proteins. CA and NC are separated by a short spacer peptide (spacer peptide 1 [SP1]) on the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein and released by… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 120 extracted citations

The triple threat of HIV-1 protease inhibitors.

Current topics in microbiology and immunology • 2015
View 6 Excerpts
Highly Influenced

Virus maturation as a new HIV-1 therapeutic target.

Expert opinion on therapeutic targets • 2009
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…