Sequential somatostatin and gastrin releases in response to secretin in rat in vivo.

@article{Rigaud1991SequentialSA,
  title={Sequential somatostatin and gastrin releases in response to secretin in rat in vivo.},
  author={Daniel Jacques Rigaud and Marcelle Dubrasquet and J. P. Accary and Jean Pierre Laigneau and Miguel J. M. Lewin},
  journal={Gastroenterologie clinique et biologique},
  year={1991},
  volume={15 10},
  pages={717-22}
}
Secretin in known to inhibit gastric acid secretion. Exogenous secretin has also been shown to have a biphasic effect on acid secretion, being stimulatory then inhibitory. To explain this effect, we studied the timing of gastrin, somatostatin, and HCl releases in the gastric lumen in response to an i.v. bolus of secretin (360 pmol) or saline in conscious rats provided with a chronic double gastric fistula and having had or not antrectomy. After secretin but not saline, an immediate and… CONTINUE READING