Sequential roles of Hedgehog and Wnt signaling in osteoblast development.

  title={Sequential roles of Hedgehog and Wnt signaling in osteoblast development.},
  author={Hongliang Hu and Matthew J Hilton and Xiaolin Tu and Kai Yu and David M Ornitz and Fanxin Long},
  volume={132 1},
Signals that govern development of the osteoblast lineage are not well understood. Indian hedgehog (Ihh), a member of the hedgehog (Hh) family of proteins, is essential for osteogenesis in the endochondral skeleton during embryogenesis. The canonical pathway of Wnt signaling has been implicated by studies of Lrp5, a co-receptor for Wnt proteins, in postnatal bone mass homeostasis. In the present study we demonstrate that beta-catenin, a central player in the canonical Wnt pathway, is… CONTINUE READING
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