Sequential role of plasmacytoid dendritic cells and regulatory T cells in oral tolerance.

@article{Dubois2009SequentialRO,
  title={Sequential role of plasmacytoid dendritic cells and regulatory T cells in oral tolerance.},
  author={Bertrand Dubois and Gr{\'e}goire Joubert and Mercedes Gomez de Ag{\"u}ero and Marie Gouanvic and Anne Goubier and Dominique Kaiserlian},
  journal={Gastroenterology},
  year={2009},
  volume={137 3},
  pages={1019-28}
}
BACKGROUND & AIMS Orally induced tolerance to environmental allergens prevents deleterious, systemic, delayed-type hypersensitivity responses via immune suppression mechanisms believed to include either anergy/deletion of specific effector T cells or active suppression by CD4(+)CD25(+) regulatory T cells (Tregs). The aim of this study was to investigate whether and how antigen (Ag) penetration through the gut orchestrates these 2 distinct mechanisms. METHODS Using a model of allergic contact… CONTINUE READING

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