Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.

@article{Suh2008SequentialRO,
  title={Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.},
  author={Sang Won Suh and Aaron M. Hamby and Elizabeth T. Gum and Byung Seop Shin and Seok Joon Won and Christian T. Sheline and Pak Hoo Chan and Raymond A Swanson},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2008},
  volume={28 10},
  pages={1697-706}
}
Oxidative stress and zinc release are both known to contribute to neuronal death after hypoglycemia; however, the cause-effect relationships between these events are not established. Here we found, using a rat model of profound hypoglycemia, that the neuronal zinc release and translocation that occur immediately after hypoglycemia are prevented by the nitric oxide synthase inhibitor 7-nitroindazole but not by overexpression of superoxide dismutase-1 (SOD-1). However, overexpression of SOD-1… CONTINUE READING