Sequential release of eicosanoids during endotoxin-induced shock in anesthetized pigs.

@article{Mozes1991SequentialRO,
  title={Sequential release of eicosanoids during endotoxin-induced shock in anesthetized pigs.},
  author={Tamar Mozes and Freek J. Zijlstra and Jan P. C. Heiligers and Pramod R. Saxena and Iv{\'a}n L. Bonta},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1991},
  volume={42 4},
  pages={209-16}
}
The release of eicosanoids during endotoxin shock was investigated in anesthetized pigs receiving 5 micrograms/kg Escherichia coli lipopolysaccharide (LPS) over 60 min into the superior mesenteric artery. TXB2, 6-keto PGF1 alpha and LTB4 concentrations in blood obtained from the superior mesenteric vein (SMV), right ventricle (RV) and aorta, during LPS infusion and an additional period of 2 h, were assessed along with hemodynamic variables, blood gases and pH and laboratory parameters. Half of… CONTINUE READING