Sequential postnatal changes in erythrocyte glutathione and sulfhydryl content: a possible adaptational response to the extrauterine environment.

@article{JeanBaptiste2003SequentialPC,
  title={Sequential postnatal changes in erythrocyte glutathione and sulfhydryl content: a possible adaptational response to the extrauterine environment.},
  author={Dominique Jean-Baptiste and N. de M. Rudolph},
  journal={Biology of the neonate},
  year={2003},
  volume={84 2},
  pages={142-6}
}
Glutathione is a key factor in intracellular antioxidant defense mechanisms. We postulated that it might modulate the adaptational response of the fetus to a higher oxygen environment after birth. Therefore, we determined total glutathione (GSH + GSSG) and non-protein sulfhydryl (-SH) content in cord blood RBC hemolysates, and sequential values in blood from the same infants for up to 72 h after birth. We noted a consistent rapid decline in total glutathione content by 24 h in both term (-18… CONTINUE READING