Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.

@article{Zhang2009SequentialPO,
  title={Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.},
  author={Xiaoyan Zhang and Qiang Chen and Jia Feng and Junjie Hou and Fuquan Yang and Junjun Liu and Qing Jiang and Chuanmao Zhang},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 13},
  pages={
          2240-51
        }
}
Nedd1 is a new member of the gamma-tubulin ring complex (gammaTuRC) and targets the gammaTuRC to the centrosomes for microtubule nucleation and spindle assembly in mitosis. Although its role is known, its functional regulation mechanism remains unclear. Here we report that the function of Nedd1 is regulated by Cdk1 and Plk1. During mitosis, Nedd1 is firstly phosphorylated at T550 by Cdk1, which creates a binding site for the polo-box domain of Plk1. Then, Nedd1 is further phosphorylated by Plk1… CONTINUE READING
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Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.

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