Sequential monotherapy of hypertension.

  title={Sequential monotherapy of hypertension.},
  author={Mahendr S. Kochar and Dominique Trottier and G Kotecki and Miriam Forbes and V S Bamrah},
  journal={Journal of clinical pharmacology},
  volume={34 12},
In most cases, the antihypertensive therapy for an individual patient is selected through a process of trial and error. This study determined if, by treating each hypertensive patient sequentially, with six antihypertensive drugs, one from each of the major classes, one could decide on the best possible drug for control of hypertension. In a randomized open-label crossover study, 19 patients (16 male and 3 female), 28-70 years of age with a sitting diastolic blood pressure of 95-110 mm Hg were… CONTINUE READING