Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces.

@article{Vanbervliet2002SequentialIO,
  title={Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces.},
  author={B{\'e}atrice Vanbervliet and Bernhard Homey and Isabelle H. Durand and Catherine Massacrier and Smina A{\"i}t-Yahia and Odette de Bouteiller and Alain Vicari and Christophe Caux},
  journal={European journal of immunology},
  year={2002},
  volume={32 1},
  pages={231-42}
}
To reach the site of antigen deposition at epithelial surfaces, dendritic cells (DC) have to traverse the endothelial barrier, progress through the tissue (i.e., dermis) and cross the dermo-epithelial junction (basal membrane). In the present study, we demonstrate that (1) circulating blood DC and monocytes express high levels of CCR2 and primarily respond to monocyte chemotactic protein (MCP) and not to macrophage inflammatory protein (MIP)-3alpha/CCL20; (2) while the CD34(+) hematopoietic… CONTINUE READING