Sequential interplay between BAG6 and HSP70 upon heat shock

  title={Sequential interplay between BAG6 and HSP70 upon heat shock},
  author={Aur{\'e}lie Corduan and Sylvain Lecomte and Carlos Mart{\'i}n and Deborah L. Michel and Fabienne Desmots},
  journal={Cellular and Molecular Life Sciences},
BAG6/Scythe/Bat3 is a cochaperone of the heat shock protein HSP70 and is involved in various developmental processes, cellular stress and viability. BAG6 interferes with the protein-refolding activity of HSP70 but its precise involvement in proteotoxic stresses remains unknown. We show that BAG6 is required for the accumulation of HSP70 upon heat shock and that conversely, once accumulated, HSP70 leads to the massive and CHIP-independent degradation of BAG6 through the ubiquitin-proteasome… CONTINUE READING

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Up - regulation of the clusterin gene after proteotoxic stress . Implication of HSF 1 / HSF 2 heterocomplex

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