Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy.

@article{Palmieri2007SequentialEO,
  title={Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy.},
  author={Orazio Palmieri and Anna Latiano and Fabrizio Bossa and Maurizio Vecchi and Renata D'inc{\'a} and Danila Guagnozzi and Francesco Tonelli and Salvatore Cucchiara and Maria Rosa Valvano and Tiziana Pia Latiano and Angelo Andriulli and Vito Annese},
  journal={Alimentary pharmacology & therapeutics},
  year={2007},
  volume={26 5},
  pages={737-45}
}
AIM To evaluate the polymorphisms of several genes involved in the azathioprine and mercaptopurine metabolism, in an attempt to explain their toxicity and efficacy in Crohn's disease and ulcerative colitis. METHODS In 422 consecutive patients (250 with Crohn's disease and 172 with ulcerative colitis) and 245 healthy controls, single nucleotide polymorphisms of thiopurine methyltransferase, inosine triphosphate pyrophosphatase and hypoxanthine phosphoribosyl transferase (HPRT1) genes were… CONTINUE READING
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