Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period.

@article{Higashiyama2007SequentialDC,
  title={Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period.},
  author={Daisuke Higashiyama and Hirotomo Saitsu and Munekazu Komada and Toshiya Takigawa and Makoto Ishibashi and Kohei Shiota},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2007},
  volume={79 7},
  pages={513-23}
}
BACKGROUND Prenatal exposure to ethanol induces holoprosencephalic malformations in both humans and laboratory animals. However, its teratogenic window for inducing holoprosencephaly is narrow, and the teratogenic mechanism is not well understood. In the present study, we examined the morphological changes in the craniofacial structures of mouse embryos/fetuses at intervals following ethanol treatment and evaluated gene expression patterns in the embryos. METHODS Pregnant C57BL/6J mice were… CONTINUE READING