Sequential determination of pharmacokinetics and pharmacodynamics of mycophenolic acid in liver transplant patients treated with mycophenolate mofetil.

@article{Brunet2006SequentialDO,
  title={Sequential determination of pharmacokinetics and pharmacodynamics of mycophenolic acid in liver transplant patients treated with mycophenolate mofetil.},
  author={Merçe Brunet and Isabel Cirera and Jaume Martorell and Elena Vidal and Olga Mill{\'a}n and Olga Lidia Jimenez and Isabel Rojo and Mar{\'i}a Carlota Londo{\~n}o and Antoni Rimola},
  journal={Transplantation},
  year={2006},
  volume={81 4},
  pages={541-6}
}
BACKGROUND In liver transplantation, mycophenolate mofetil (MMF) is habitually administered using fixed doses. We assessed whether mycophenolic acid (MPA) monitoring could be advisable in liver transplant patients. METHODS In 15 liver transplant patients receiving tacrolimus, daclizumab and MMF (1 g bid, orally), we determined the 12-hour plasma MPA pharmacokinetic profile after one dose of MMF at days 6, 10, and 16, and months 3 and 6. The inhibitory capacity of serum MPA on proliferation of… CONTINUE READING

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