Sequential construction of a model for modular gene expression control, applied to spatial patterning of the Drosophila gene hunchback

@article{Spirov2016SequentialCO,
  title={Sequential construction of a model for modular gene expression control, applied to spatial patterning of the Drosophila gene hunchback},
  author={Alexander V. Spirov and Ekaterina M. Myasnikova and David M. Holloway},
  journal={Journal of bioinformatics and computational biology},
  year={2016},
  volume={14 2},
  pages={
          1641005
        }
}
Gene network simulations are increasingly used to quantify mutual gene regulation in biological tissues. These are generally based on linear interactions between single-entity regulatory and target genes. Biological genes, by contrast, commonly have multiple, partially independent, cis-regulatory modules (CRMs) for regulator binding, and can produce variant transcription and translation products. We present a modeling framework to address some of the gene regulatory dynamics implied by this… CONTINUE READING
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