Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty.

@article{Badaru2006SequentialCO,
  title={Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty.},
  author={Angela Badaru and Darrell M. Wilson and Laura Keyes Bachrach and Patricia Y. Fechner and Laura M Gandrud and Eileen Durham and Kupper A. Wintergerst and Carolyn H Chi and Karen Oerter Klein and Elizabeth Neely},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 5},
  pages={1862-7}
}
BACKGROUND Dosing of monthly depot leuprolide (DL) in central precocious puberty (CPP) varies considerably. U.S. practitioners use 7.5-15 mg, in contrast with the international standard of 3.75 mg. Pubertal suppression using the newer 3-month DL also has been reported from Europe. To date there have been no direct comparisons of these different DL doses. OBJECTIVES In an open 12-month protocol, we tested the efficacy of three DL doses (7.5 mg- and 3.75 mg-1 month and 11.25 mg-3 month) given… CONTINUE READING

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