Sequential combination of two intravenous thrombolytics (recombinant tissue plasminogen activator/tenecteplase) in a patient with stroke and cardioembolic basilar artery occlusion.

Abstract

Stroke caused by acute occlusion of basilar artery (AOBA) produces high risk of death. In eligible patients, thrombolysis significantly reduces mortality and disability rate. In most hospitals, thrombolysis is limited to intravenous (IV) route of recombinant tissue plasminogen activator, without any therapeutic alternative in cases of treatment failure. We report a case of cardioembolic AOBA, not responsive to a conventional regimen of IV recombinant tissue plasminogen activator. A sequential combination of IV tenecteplase (0.4 mg/kg) led to a complete recanalization of basilar artery, with a very good clinical outcome. The potential for a combination of two successive IV regimens should be evaluated in AOBA.

DOI: 10.1016/j.jstrokecerebrovasdis.2008.08.001

Cite this paper

@article{Smadja2009SequentialCO, title={Sequential combination of two intravenous thrombolytics (recombinant tissue plasminogen activator/tenecteplase) in a patient with stroke and cardioembolic basilar artery occlusion.}, author={Didier Smadja and St{\'e}phane Olindo and Martine Saint-Vil and Nicolas Chausson}, journal={Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association}, year={2009}, volume={18 1}, pages={68-71} }